Google Scholar:
Education:
Postdoctoral Fellowship, Stanford University
PhD, Neuroscience, University of Houston
MS, Neurology, Central South University
MD, Shandong Second Medical University
Research Interests:
Mechanisms of epilepsy, brain damage and repair following ischemic stroke and trauma, Alzheimer's disease.
Selected Publications:
Gu F, Parada I, Yang T, Longo FM, Prince DA. Chronic partial TrkB activation reduces seizures and mortality in a mouse model of Dravet syndrome. Proc Natl Acad Sci U S A. 2022 Feb 15;119(7):e2022726119.
Perez-Ramirez MB, Gu F, Prince DA. Prolonged prophylactic effects of gabapentin on status epilepticus-induced neocortical injury. Neurobiol Dis. 2020 Aug;142:104949.
Gu F, Parada I, Yang T, Longo FM, Prince DA. Partial Activation of TrkB Receptors Corrects Interneuronal Calcium Channel Dysfunction and Reduces Epileptogenic Activity in Neocortex following Injury. Cereb Cortex. 2020 Jul 30;30(9):5180-5189.
Gu F, Parada I, Yang T, Longo FM, Prince DA. Partial TrkB receptor activation suppresses cortical epileptogenesis through actions on parvalbumin interneurons. Neurobiol Dis. 2018 May;113:45-58.
Gu F, Parada I, Shen F, Li J, Bacci A, Graber K, Taghavi RM, Scalise K, Schwartzkroin P, Wenzel J, Prince DA. Structural alterations in fast-spiking GABAergic interneurons in a model of posttraumatic neocortical epileptogenesis. Neurobiol Dis. 2017 Dec;108:100-114.
Faria LC*, Gu F*, Parada I, Barres B, Luo ZD, Prince DA. Epileptiform activity and behavioral arrests in mice overexpressing the calcium channel subunit α2δ-1. Neurobiol Dis. 2017 Jun;102:70-80. (* equal contribution).
Kim SY, Senatorov VV Jr, Morrissey CS, Lippmann K, Vazquez O, Milikovsky DZ, Gu F, Parada I, Prince DA, Becker AJ, Heinemann U, Friedman A, Kaufer D. TGFβ signaling is associated with changes in inflammatory gene expression and perineuronal net degradation around inhibitory neurons following various neurological insults. Sci Rep. 2017 Aug 9;7(1):7711
Hosseini-Zare MS, Gu F, Abdulla A, Powell S, Žiburkus J. Effects of experimental traumatic brain injury and impaired glutamate transport on cortical spreading depression. Exp Neurol. 2017 Sep;295:155-161.
Takahashi DK, Gu F, Parada I, Vyas S, Prince DA. Aberrant excitatory rewiring of layer V pyramidal neurons early after neocortical trauma. Neurobiol Dis. 2016 Jul;91:166-81.
Prince DA, Gu F, Parada I. Antiepileptogenic repair of excitatory and inhibitory synaptic connectivity after neocortical trauma. Prog Brain Res. 2016;226:209-27.
Gu F, Hazra A, Aulakh A, Žiburkus J. Purinergic control of hippocampal circuit hyperexcitability in Dravet syndrome. Epilepsia. 2014 Feb;55(2):245-55.
Hazra A*, Gu F*, Aulakh A, Berridge C, Eriksen JL, Ziburkus J. Inhibitory neuron and hippocampal circuit dysfunction in an aged mouse model of Alzheimer's disease. PLoS One. 2013 May 17;8(5):e64318. (* equal contribution).