Gail Shadle, B.S. | Department of Biological Sciences
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Gail Shadle, B.S.

Research Scientist 1
Office: 
Room #B328
Department of Biological Sciences, College of Arts and Sciences, University of North Texas, Denton, TX 76203
940-565-4532
Gail.Shadle@unt.edu
Education: 
B.S. Biology/Chemistry, Lock Haven University of Pennsylvania, Lock Haven, PA - 1999
Research: 
Feb/2013 - present Research Scientist 1, (Supervisor: Dr. Richard A. Dixon) Department of Biological Sciences, University of North Texas.
Jan/2006 - Jan/2013 Research Associate, (Supervisor: Dr. Richard A. Dixon) the Samuel Roberts Noble Foundation, Plant Biology Division.
June/1999 - Dec/2005 Research Assistant. (Supervisor: Dr. Richard A. Dixon) the Samuel Roberts Noble Foundation, Plant Biology Division.
Jan/1999 - May 1999 Laboratory Assistant. Lock Haven University of Pennsylvania, Biochemistry laboratory.
Aug/1998 - Dec/1998 Laboratory Assistant. (Supervisor: Dr. Ted Nuttall) Lock Haven University of Pennsylvania, Cellular and Molecular Biology laboratory.
Publications: 
  1. Zhao, J., Huhman, D.V., Shadle, G., He, X-Z., Sumner, L.W., Tang, Y. and Dixon, R. A. (2011). MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula. Plant Cell, 23, 1536-1555.
  2. Zhou, R., Jackson, L., Shadle, G., Nakashima, J., Temple, S., Chen, F. and Dixon, R.A. (2010). Distinct cinnamoyl CoA reductases involved in parallel routes to lignin in Medicago truncatula. Proceedings of the National Academy of Sciences USA 107 (41), 17803-17808.
  3. Jackson, L., Shadle, G., Zhou, R., Nakashima, J., Chen, F. and Dixon, R.A. (2008). Improving saccharification efficiency of alfalfa stems through modification of the terminal stages of monolignol biosynthesis. BioEnergy Research 1, 180-192.
  4. Nakashima, J., Chen, F., Jackson, L., Shadle, G. and Dixon, R.A. (2008). Multi-site genetic modification of monolignol biosynthesis in alfalfa (Medicago sativa L.) : effects on lignin composition in specific cell types. New Phytologist 179, 738-750.
  5. Shadle, G., Chen, F., Reddy, M.S.S., Jackson, L., Nakashima, J. and Dixon, R.A. (2007). Down-regulation of hydroxycinnamoyl CoA:shikimate hydroxycinnamoyl transferase in transgenic alfalfa affects lignification, development and forage quality. Phytochemistry 68, 1521-1529.
  6. Chen, F., Reddy, M.S.S., Temple, S., Jackson, L., Shadle, G. and Dixon, R.A. (2006) Multi-site genetic modulation of monolignol biosynthesis suggests new routes for the formation of syringyl lignin and wall-bound ferulic acid in alfalfa (Medicago sativa L.). Plant Journal 48, 113-124.
  7. Reddy, M.S.S., Chen, F., Shadle, G., Jackson, L., Aljoe, H. and Dixon, R.A. (2005). Targeted down-regulation of cytochrome P450 enzymes for forage quality improvement in alfalfa (Medicago sativa L.). Proceedings of the National Academy of Sciences USA 102, 16573-16578.
  8. Suzuki, H., Xia, Y., Cameron, R., Shadle, G., Blount, J., Lamb, C. and Dixon, R.A. (2004). Signals for local and systemic responses of plants to pathogen attack. Journal of Experimental Botany 55, 169-179.
  9. Shadle, G., Wesley, S.V., Korth, K. L., Chen, F., Lamb, C. and Dixon, R.A. (2003). Phenylpropanoid compounds and disease resistance in transgenic tobacco with altered expression of L-phenylalanine ammonia-lyase. Phytochemistry 64, 153-161.
  1. Jackson, L., Chen, F., Nakashima, J., Shadle, G., and Dixon, R.A. "Cinnamoyl CoA reductase down-regulation and its impact on forage quality in alfalfa (Medicago sativa)." American Society of Plant Biologists, July 7-11, 2007, Chicago, IL.
  2. Shadle, G., Chen, F., Jackson, L., and Dixon, R.A. "Down-regulation of cinnamyl alcohol dehydrogenase and its impact on forage quality in alfalfa (Medicago sativa)." American Society of Plant Biologists, July 7-11, 2007, Chicago, IL.
  3. Jackson, L., Chen, F., Nakashima, J., Shadle, G., Reddy, M.S.S. and Dixon, R.A. "Studying monolignol biosynthesis in alfalfa by the down-regulation of Cinnamoyl CoA reductase." Phytochemical Society of North America Annual Meeting, July 8-12, 2006, Oxford, MS.
  4. Shadle, G., Chen, F., Nakashima, J., Jackson, L., Reddy, M.S.S. and Dixon, R.A. "Effects of down-regulation of HCT on lignin in alfalfa." Phytochemical Society of North America Annual Meeting, July 8-12, 2006, Oxford, MS.
  5. Nakashima, J., Reddy, M.S.S., Chen, F., Shadle, G., Jackson, L., and Dixon, R.A. "Down-regulation of key enzymes in the monolignol pathway: effects on lignin composition in specific cell types of alfalfa (Medicago sativa L.)" Phytochemical Society of North America Annual Meeting, July 8-12, 2006, Oxford, MS.
  6. Jackson, L., Reddy, M.S.S., Shadle, G., Chen, F., and Dixon, R.A. "p-Coumarate 3 -hydroxylase down-regulation in alfalfa and its impact on monolignol biosynthesis." American Society of Plant Biologists, July 16-20, 2005, Seattle, WA.
  7. Reddy, M.S.S, Chen, F.,, Shadle, G., Jackson, L., and Dixon, R.A. "Understanding monolignol biosynthesis in Medicago sativa by a reverse genetics approach." American Society of Plant Biologists, July 24-28, 2004, Orlando, FL.
  8. Shadle, G., Jackson, L., Reddy, M.S.S, Chen, F.,, and Dixon, R.A "Modification of Lignin in Medicago by Down-Regulation of Ferulate 5-Hydroxylase." Society for In Vitro Biology Annual Meeting, May 22-26, 2004, San Francisco, CA.
  9. Jackson, L., Shadle, G., Reddy, M.S.S, Chen, F.,, and Dixon, R.A. "Understanding monolignol biosynthesis in Medicago by downregulation of p-coumarate 3-hydroxylase." Society for In Vitro Biology Annual Meeting, May 22-26, 2004, San Francisco, CA.
  10. He, X.Z., Suzuki, H., Achnine, L., Shadle, G., Jackson, L., Clouse, J. and Dixon, R.A. "Characterization of squalene epoxidase promoter in tobacco cell suspension cultures." XVth International Plant Protection Congress, May 11-16, 2004, Beijing, China.
  11. Jackson, L., Shadle, G., Reddy, M.S.S, Chen, F.,, and Dixon, R.A. "A reverse genetics approach to lignin modification in Medicago." Phytochemical Society of North America Annual Meeting, August 9-13, 2003, Peoria, IL.
  12. He, X.Z., Suzuki, H., Achnine, L., Shadle, G., Clouse, J., and Dixon, R.A. "Differential regulation of squalene epoxidase in response to methyl jasmonate induction in tobacco and alfalfa cell suspension cultures." Gordon Conference in Agricultural Science, April 2003, Ventura, CA.
  13. Shadle, G., Reddy, M.S.S, Jackson, L., Chen, F.,, and Dixon, R.A. "A reverse genetics approach to study the biosynthesis of monolignols in Medicago." Second Oklahoma Minisymposium in Molecular Plant Biology, March 20-21, 2003, Stillwater, OK.
  14. Deavours, B.E., Steele, C., Shadle, G., and Dixon, R.A. "Metabolic engineering of isoflavonoid biosynthesis in alfalfa." Second Oklahoma Minisymposium in Molecular Plant Biology, March 20-21, 2003, Stillwater, OK.
  15. Shadle, G., Wesley, S.V., Korth, K. L., Chen, F., Lamb, C., and Dixon, R.A. "Over-expression of L-phenylalanine ammonia-lyase improves plant resistance to viral, fungal, and bacterial pathogens." XXI International Conference on Polyphenols, September 9-12, 2002, Marrakech, Morocco.
  16. Boydston, C., Riner, L., Shadle, G., Allen, S., Dixon, R.A, May, G., Paiva, N.L., and Harrison, M.J. "Insertional mutagenesis of Medicago truncatula." 4th Workshop on Medicago truncatula, July 7-10, 2001, Madison, WI.