BioFrontiers Biology Seminar Presents Dr. Paul B. McCray September 25; 3:00PM | Department of Biological Sciences

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October 31, 2019

BioFrontiers Biology Seminar Presents Dr. Paul B. McCray September 25; 3:00PM

BioFrontiers - Biology Seminar September 25, 2020

Zoom Meeting: https://unt.zoom.us/j/98067606539

Dr. Paul B. McCray, Professor, Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa
Gene therapy strategies for the treatment of cystic fibrosis lung disease Dr. McCray is Professor of Pediatrics, Microbiology & Immunology, and Internal Medicine
at the University of Iowa. He is the Executive Vice Chair in the Department of Pediatrics, Associate Director of the Center for Gene Therapy of Cystic Fibrosis, and holds
the Roy J. Carver Chair in Pulmonary Research.

He is a member of the American Society for Clinical Investigation, the American Pediatric Society, the Association of American Physicians, the American Association for the Advancement
of Science, and the American Academy of Microbiology. As a pediatric pulmonologist, Dr. McCray has long-standing interests in cystic fibrosis, host-pathogen interactions, airway epithelial biology, pulmonary innate
immune responses, and the applications of gene transfer for lung diseases. One focus of his laboratory program has been the application of gene therapy approaches to the treatment and prevention of cystic fibrosis
lung disease. Dr. McCray's work is supported by NIH and the Cystic Fibrosis Foundation. This seminar will provide an overview of gene addition and gene editing approaches for the treatment and prevention of lung disease caused by cystic fibrosis. Recent progress with lentiviral vectors and adenine base editors will be a focus. Immunofluorescence microscopy image of the large airways of a mouse showing GFP protein delivery toairway epithelia using amphiphilic peptides Department.